Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

  title={Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.},
  author={Amanda L. Hernandez and Alexandra Kitz and Chuan Wu and Daniel E. Lowther and Donald M. Rodriguez and Nalini Kumar Vudattu and Songyan Deng and Kevan C Herold and Vijay K Kuchroo and Markus Kleinewietfeld and David A. Hafler},
  journal={The Journal of clinical investigation},
  volume={125 11},
FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is partially mediated by a population of IFNγ-secreting Tregs. It was previously reported that increased NaCl concentrations promote the induction of proinflammatory Th17 cells and that high-salt diets exacerbate experimental models of autoimmunity. Here, we have shown that increasing NaCl, either in vitro or in murine… CONTINUE READING


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