Sodium channels in normal and pathological pain.

@article{DibHajj2010SodiumCI,
  title={Sodium channels in normal and pathological pain.},
  author={Sulayman D. Dib-Hajj and Theodore R. Cummins and J Andrew Black and Stephen G. Waxman},
  journal={Annual review of neuroscience},
  year={2010},
  volume={33},
  pages={325-47}
}
Nociception is essential for survival whereas pathological pain is maladaptive and often unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na(v)1.1-Na(v)1.9, are essential for generation and conduction of electrical impulses in excitable cells. Human and animal studies have identified several channels as pivotal for signal transmission along the pain axis, including Na(v)1.3, Na(v)1.7, Na(v)1.8, and Na(v)1.9, with the latter three preferentially expressed in peripheral sensory… CONTINUE READING
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