Sodium channels, the electrogenisome and the electrogenistat: lessons and questions from the clinic.

@article{Waxman2012SodiumCT,
  title={Sodium channels, the electrogenisome and the electrogenistat: lessons and questions from the clinic.},
  author={Stephen G. Waxman},
  journal={The Journal of physiology},
  year={2012},
  volume={590 11},
  pages={2601-12}
}
In the six decades that have followed the work of Hodgkin and Huxley, multiple generations of neuroscientists and biophysicists have built upon their pivotal contributions. It is now clear that, in mammals, nine genes encode nine distinct voltage-gated sodium channels with different amino acid sequences and different physiological and pharmacological properties. The different sodium channel isoforms produce a multiplicity of distinct sodium currents with different time-dependent characteristics… CONTINUE READING
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