Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione

@article{Mitrovi1993SodiumCI,
  title={Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione},
  author={Nenad R. Mitrovi{\'c} and Stefan Quasthoff and Peter Grafe},
  journal={Pfl{\"u}gers Archiv},
  year={1993},
  volume={425},
  pages={453-461}
}
Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single-channel currents were investigated. In the axon-attached mode, inactivation of multi-channel Na+ currents in sensory axons was best fitted with a single time constant while for motor axons two time constants were needed. Late single-channel… CONTINUE READING

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