Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency.

@article{Goldman1995SodiumCI,
  title={Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency.},
  author={L Elizabeth Goldman},
  journal={Biophysical journal},
  year={1995},
  volume={69 6},
  pages={2369-77}
}
The time course of Na channel inactivation from closed states was determined on inside-out excised patches from neuroblastoma N1E 115. Closed-state inactivation develops as a single exponential with mean time constants of 66.4 ms at -80 mV, 29.6 ms at -70 mV, 20.1 ms at -60 mV, and 15.1 ms at -50 mV. Corresponding mean steady-state values of the fitted exponentials were 0.321, 0.098, 0.035, and 0. Closed-state inactivation, in general, should develop either with a delay or as more than one… CONTINUE READING

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