Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice.

@article{Vabnick1997SodiumCD,
  title={Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice.},
  author={I Vabnick and Albee Messing and Shing Yan Chiu and Simon Rock Levinson and Melitta Schachner and John Roder and Chanxia Li and Sanja M. Novakovi{\'c} and Peter G Shrager},
  journal={Journal of neuroscience research},
  year={1997},
  volume={50 2},
  pages={
          321-36
        }
}
Na+ channel organization was studied with immunofluorescence in the peripheral nervous system of mice genetically altered to produce abnormal myelin. In two of these strains, transcription of inserted transgenes was targeted to myelinating Schwann cells through linkage to a promoter for the myelin protein P0. Adults of both of these strains had hindlimb paralysis and a tremor on lifting by the tail. In one case, Schwann cells were eliminated via expression of the diphtheria toxin A chain (DT-A… CONTINUE READING
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