Sodium channel blockers as therapeutic target for treating epilepsy: recent updates.

@article{Zuliani2012SodiumCB,
  title={Sodium channel blockers as therapeutic target for treating epilepsy: recent updates.},
  author={Valentina Zuliani and Marco Fantini and Mirko Rivara},
  journal={Current topics in medicinal chemistry},
  year={2012},
  volume={12 9},
  pages={
          962-70
        }
}
The voltage-gated sodium channels (VGSCs) are a family of membrane proteins forming a pore, through which they selectively conduct sodium ions inward and outward cell's plasma membranes in response to variations of membrane potentials, playing a fundamental role in controlling cellular excitability. Growing evidences suggest that abnormal VGSCs are involved in the pathophysiology of both acquired and inherited epilepsy. Approximately two dozen drugs are currently marketed for the treatment of… CONTINUE READING
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