Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.

  title={Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.},
  author={Mark C P Haigney and Edward G. Lakatta and Michael D. Stern and H. S. Silverman},
  volume={90 1},
BACKGROUND Studies have shown that the rise in intracellular ionized calcium, [Ca2+]i, in hypoxic myocardium is driven by an increase in sodium, [Na+]i, but the source of Na+ is not known. METHODS AND RESULTS Inhibitors of the voltage-gated Na+ channel were used to investigate the effect of Na+ channel blockade on hypoxic Na+ loading, Na(+)-dependent Ca2+ loading, and reoxygenation hypercontracture in isolated adult rat cardiac myocytes. Single electrically stimulated (0.2 Hz) cells were… CONTINUE READING


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