Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

Abstract

Marked hypersensitivity to heat and mechanical (pressure) stimuli develop after a burn injury, but the neural mechanisms underlying these effects are poorly understood. In this study, we establish a new mouse model of focal second-degree burn injury to investigate the molecular and cellular basis for burn injury-induced pain. This model features robust… (More)
DOI: 10.1523/JNEUROSCI.0304-12.2012

Topics

9 Figures and Tables

Cite this paper

@article{Shields2012SodiumCN, title={Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.}, author={Shannon D. Shields and Xiaoyang Cheng and Nurcan Uçeyler and Claudia Sommer and Sulayman D. Dib-Hajj and Stephen G. Waxman}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2012}, volume={32 32}, pages={10819-32} }