Sodium channel (dys)function and cardiac arrhythmias.

  title={Sodium channel (dys)function and cardiac arrhythmias.},
  author={Carol Ann Remme and Connie R. Bezzina},
  journal={Cardiovascular therapeutics},
  volume={28 5},
Cardiac voltage-gated sodium channels are transmembrane proteins located in the cell membrane of cardiomyocytes. Influx of sodium ions through these ion channels is responsible for the initial fast upstroke of the cardiac action potential. This inward sodium current thus triggers the initiation and propagation of action potentials throughout the myocardium and consequently plays a central role in excitability of myocardial cells and proper conduction of the electrical impulse within the heart… CONTINUE READING