Sodium-calcium ion exchange in cardiac membrane vesicles.

  title={Sodium-calcium ion exchange in cardiac membrane vesicles.},
  author={John P. Reeves and John L. Sutko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 2},
Membrane vesicles isolated from rabbit ventricular tissue rapidly accumulated Ca2+ when an outwardly directed Na+ gradient was formed across the vesicle membrane. Vesicles loaded internally with K+ showed only 10% of the Ca2+ uptake activity observed with Na+-loaded vesicles. Dissipation of the Na+ gradient with the monovalent cation exchange ionophores nigericin or narasin caused a rapid decline in Ca2+ uptake activity. The Ca2+-ionophore A23187 inhibited Ca2+ uptake by Na+-loaded vesicles and… CONTINUE READING
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