Sodium-calcium exchanger in cultured human retinal pigment epithelium.

  title={Sodium-calcium exchanger in cultured human retinal pigment epithelium.},
  author={Nancy J. Mangini and L M Haugh-Scheidt and Jaione Valle and Edward J. Cragoe and Harris Ripps and Brian G. Kennedy},
  journal={Experimental eye research},
  volume={65 6},
Regulation of intracellular free Ca2+ concentration ([Ca2+]i) by an Na+/Ca2+ exchanger was studied in cultures of human retinal pigment epithelial cells using Ca(2+)-indicator dyes (fura-2 and fluo-3) and digital fluorescence imaging. Mean resting [Ca2+]i of cultured RPE in a control Ringer solution was 189 +/- 16 nM. Replacing extracellular Na+ with N-methyl-D-glucamine elicited a two-fold rise in [Ca2+]i; the magnitude of the [Na+]o-free-induced rise in [Ca2+]i varied as a function of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Ion channels in the RPE.

Progress in retinal and eye research • 2007
View 4 Excerpts
Highly Influenced

The retinal pigment epithelium in visual function.

Physiological reviews • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…