Sodium-calcium exchanger in cultured human retinal pigment epithelium.

@article{Mangini1997SodiumcalciumEI,
  title={Sodium-calcium exchanger in cultured human retinal pigment epithelium.},
  author={Nancy J. Mangini and L M Haugh-Scheidt and Jaione Valle and Edward J. Cragoe and Harris Ripps and Brian G. Kennedy},
  journal={Experimental eye research},
  year={1997},
  volume={65 6},
  pages={821-34}
}
Regulation of intracellular free Ca2+ concentration ([Ca2+]i) by an Na+/Ca2+ exchanger was studied in cultures of human retinal pigment epithelial cells using Ca(2+)-indicator dyes (fura-2 and fluo-3) and digital fluorescence imaging. Mean resting [Ca2+]i of cultured RPE in a control Ringer solution was 189 +/- 16 nM. Replacing extracellular Na+ with N-methyl-D-glucamine elicited a two-fold rise in [Ca2+]i; the magnitude of the [Na+]o-free-induced rise in [Ca2+]i varied as a function of… CONTINUE READING

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