Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner.

@article{Lee2017SodiumBI,
  title={Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner.},
  author={Changhyun Lee and Byeong Gwan Kim and Jee Hyun Kim and Jaeyoung Chun and Jong Pil Im and Joo Sung Kim},
  journal={International immunopharmacology},
  year={2017},
  volume={51},
  pages={47-56}
}
Butyrate is a bacterial metabolite of dietary fiber in the colon that has been used to treat inflammatory disease. However, the effect of oral supplementation with butyrate on colitis has not been fully explored. We evaluated the effects of and mechanisms underlying oral supplementation with butyrate on experimental murine colitis. In an in vitro study, we found that LPS induced the secretion of cytokines (i.e., IL-8 in COLO 205; TNF-α, IL-6, IL-12, and IL-10 in RAW 264.7; and TNF-α, IL-6 and… CONTINUE READING

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