Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review.

@article{Fujii2019SodiumBT,
  title={Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review.},
  author={Tomoko Fujii and Andrew A Udy and Elisa Licari and Lorena Romero and Rinaldo Bellomo},
  journal={Journal of critical care},
  year={2019},
  volume={51},
  pages={
          184-191
        }
}
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References

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Bicarbonate in diabetic ketoacidosis - a systematic review
TLDR
The evidence to date does not justify the administration of bicarbonate for the emergent treatment of DKA, especially in the pediatric population, in view of possible clinical harm and lack of sustained benefits.
Safety and efficacy of intravenous Carbicarb® in patients undergoing surgery: Comparison with sodium bicarbonate in the treatment of mild metabolic acidosis
TLDR
Carbicarb corrects metabolic acidosis as well as sodium bicarbonate, however, the potential therapeutic advantage of Carbicarb remains to be determined, especially in patients with more severe metabolic Acidosis.
Sodium bicarbonate supplements for treating acute kidney injury.
TLDR
There is an urgent need for well conducted RCTs in this area and no RCT evidence - supportive or otherwise - for the use of sodium bicarbonate for people with AKI is found.
Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group.
TLDR
Administration of sodium bicarbonate to well-oxygenated patients with mild metabolic acidosis resulted in a correction of the acidosis, without significant changes in cardiac output, total body oxygen use, or PaO2 (oxygen tension).
Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: A prospective, controlled clinical study
TLDR
Administration of sodium bicarbonate did not improve hemodynamic variables in patients with lactic acidosis, but did not worsen tissue oxygenation.
Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial.
TLDR
This study investigated if bicarbonate therapy improves the rate of increase of arterial pH and to find out its effects on the recovery rate of the other metabolic abnormalities in patients with severe diabetic ketoacidosis.
Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis.
TLDR
Sodium bicarbonate and THAM had a similar alkalinizing effect in patients with mild metabolic acidosis; however, the effect of sodium bICarbonate was longer lasting and therefore THAM is therefore not recommended in patient with hyperkalemia.
Does bicarbonate therapy improve the management of severe diabetic ketoacidosis?
TLDR
Data from the literature and this study are not in favor of the use of bicarbonate in the treatment of diabetic ketoacidosis with pH values between 6.90 and 7.10.
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