Sodium benzoate‐induced repeated episodes of acute urticaria/angio‐oedema: randomized controlled trial

  title={Sodium benzoate‐induced repeated episodes of acute urticaria/angio‐oedema: randomized controlled trial},
  author={Eustachio Nettis and Maria Cristina Colanardi and Antonio Ferrannini and Alfredo Tursi},
  journal={British Journal of Dermatology},
Background  Sodium benzoate (E 211) is widely used to delay yeast spoilage of acidic foods and beverages. Numerous cases of adverse reactions to benzoate have been recorded, but most of the studies that have been conducted lacked proper placebo controls or blinding. 

Trifluoperazine-Induced Angioedema

The case of a 44-year-old male with an established diagnosis of schizoaffective disorder, for which trifluoperazine therapy was considered, who presented to the emergency department with bilateral lower limb oedematous painful erythematous swelling that eased off completely when trifLUoperazine was stopped.

Contact allergy to topical diclofenac with systemic tolerance

It is emphasized the importance of a timely recognition of isolated contact urticaria to SB-containing drugs upon contact with the skin, which does not automatically mean they can no longer be used orally, so unnecessary elimination, and/or the use of alternative drugs, can be avoided.

The Personalized Treatment for Urticaria

Personalized treatment in urticaria is a very important aspect as many urticaria patients have very special triggering factors and also many have a special need for treatment.

Urticaria: selected highlights and recent advances.

Sodium benzoate for treatment of hepatic encephalopathy.

Sodium benzoate is an inexpensive adjunctive agent that can be used in addition to lactulose and rifaximin and may provide an option for some select patients with refractory HE who have failed to respond to standard therapies or who cannot afford them.

EAACI/GA2LEN/EDF guideline: management of urticaria

The recommended first line treatment are nonsedating H1 antihistamines, but dosages increased up to fourfold over the recommended doses may be necessary for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment.

Hypersensitivity Reactions to Food Additives—Preservatives, Antioxidants, Flavor Enhancers

It is concluded that it is necessary to conduct randomised multicentre studies based on the double-blind placebo control protocol in this field, to systematise knowledge about selected groups of food additives and the HFA induced by them.

Food Additives and Allergic Diseases in Childhood

In conclusion, the exact relationship between food additives and the allergic diseases still remains to be solved.

Adverse reactions to food additives in children: A retrospective study and a prospective survey.

Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology

A methodologic approach based on classification, pathophysiology, impact on quality of life, diagnosis and prognosis, differential diagnosis and management of all the types of urticaria is described.



Edematous allergic contact cheilitis from a toothpaste

Because of their efficacy and relatively low incidence of side-effects, P-blockers are widely used agents for the treatment of intra-ocular hypertension and this patient confirms this previous finding of contact dermatitis from levobunolol.

Efficacy of leukotriene receptor antagonist in chronic urticaria. A double‐blind, placebo‐controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid

The clinical efficacy and safety of montelukast and cetirizine are compared in the treatment of patients with chronic urticaria who have positive challenge to acetylsalicylic acid (ASA) and/or food additives.

Food additives and allergy.

Evidence does suggest that there is a small subset of primarily younger children in whom additives will impact on behavior, and the problem appears to be much smaller than originally postulated.

Food additives and allergy.

Evidence does suggest that there is a small subset of primarily younger children in whom additives will impact on behavior, and the problem appears to be much smaller than originally postulated.

Clinical relevance of food additives in adult patients with atopic dermatitis

  • WormEhlersSterryZuberbier
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2000
To date the role of pseudoallergic reactions as an aggravating factor in AD of adult patients remains controversial, however, many adult patients report on food‐related aggravation of the disease and nonallergic hypersensitivity reactions have been incriminated repeatedly.

Release of mediators from human gastric mucosa and blood in adverse reactions to benzoate.

The results suggest a possible involvement of prostacyclin and histamine in adverse reactions to benzoate and a mediator release from mucosa can already be demonstrated in a preclinical state of the pseudoallergic reaction in the absence of clinical symptoms.

Food allergy: When and how to perform oral food challenges

  • S. Sicherer
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1999
Since childhood food allergies to common allergenic foods such as milk, egg, wheat and soy are usually outgrown, oral food challenges are also an integral part of the long‐term management of these children.

A revised nomenclature for allergy: An EAACI position statement from the EAACI nomenclature task force

The aim of this report is to propose a revised nomenclature for allergic and related reactions that can be used independently of target organ or patient age group.