Sodium benzoate‐induced repeated episodes of acute urticaria/angio‐oedema: randomized controlled trial

@article{Nettis2004SodiumBR,
  title={Sodium benzoate‐induced repeated episodes of acute urticaria/angio‐oedema: randomized controlled trial},
  author={Eustachio Nettis and Maria Cristina Colanardi and Antonio Ferrannini and Alfredo Tursi},
  journal={British Journal of Dermatology},
  year={2004},
  volume={151}
}
Background  Sodium benzoate (E 211) is widely used to delay yeast spoilage of acidic foods and beverages. Numerous cases of adverse reactions to benzoate have been recorded, but most of the studies that have been conducted lacked proper placebo controls or blinding. 

Trifluoperazine-Induced Angioedema

The case of a 44-year-old male with an established diagnosis of schizoaffective disorder, for which trifluoperazine therapy was considered, who presented to the emergency department with bilateral lower limb oedematous painful erythematous swelling that eased off completely when trifLUoperazine was stopped.

Contact allergy to topical diclofenac with systemic tolerance

It is emphasized the importance of a timely recognition of isolated contact urticaria to SB-containing drugs upon contact with the skin, which does not automatically mean they can no longer be used orally, so unnecessary elimination, and/or the use of alternative drugs, can be avoided.

The Personalized Treatment for Urticaria

Personalized treatment in urticaria is a very important aspect as many urticaria patients have very special triggering factors and also many have a special need for treatment.

Urticaria: selected highlights and recent advances.

Sodium benzoate for treatment of hepatic encephalopathy.

Sodium benzoate is an inexpensive adjunctive agent that can be used in addition to lactulose and rifaximin and may provide an option for some select patients with refractory HE who have failed to respond to standard therapies or who cannot afford them.

EAACI/GA2LEN/EDF guideline: management of urticaria

The recommended first line treatment are nonsedating H1 antihistamines, but dosages increased up to fourfold over the recommended doses may be necessary for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment.

Hypersensitivity Reactions to Food Additives—Preservatives, Antioxidants, Flavor Enhancers

It is concluded that it is necessary to conduct randomised multicentre studies based on the double-blind placebo control protocol in this field, to systematise knowledge about selected groups of food additives and the HFA induced by them.

Food Additives and Allergic Diseases in Childhood

In conclusion, the exact relationship between food additives and the allergic diseases still remains to be solved.

Adverse reactions to food additives in children: A retrospective study and a prospective survey.

Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology

A methodologic approach based on classification, pathophysiology, impact on quality of life, diagnosis and prognosis, differential diagnosis and management of all the types of urticaria is described.
...

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