Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction.

Abstract

Arsenic can induce reactive oxygen species (ROS) leading to oxidative stress and carcinogenesis. Bladder is one of the major target organs of arsenic, and cyclooxygenase-2 (COX-2) may play an important role in arsenic-induced bladder cancer. However, the mechanism by which arsenic induces COX-2 in bladder cells remains unclear. This study aimed at… (More)
DOI: 10.1016/j.tiv.2013.01.012

Topics

Cite this paper

@article{Wang2013SodiumAI, title={Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction.}, author={Huihui Wang and Shuhua Xi and Yuanyuan Xu and Fei Wang and Yi Zheng and Bing Li and Xin Li and Quanmei Zheng and Guifan Sun}, journal={Toxicology in vitro : an international journal published in association with BIBRA}, year={2013}, volume={27 3}, pages={1043-8} }