Sodium and potassium in the pathogenesis of hypertension.

@article{Adrogu2007SodiumAP,
  title={Sodium and potassium in the pathogenesis of hypertension.},
  author={Horacio J. Adrogu{\'e} and Nicolaos E Madias},
  journal={The New England journal of medicine},
  year={2007},
  volume={356 19},
  pages={
          1966-78
        }
}
This review examines epidemiologic, physiological, and molecular evidence that the interplay between sodium and potassium is central to the development of hypertension. The review concludes with recommendations for reducing sodium and increasing potassium in the diet. 
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References

SHOWING 1-10 OF 105 REFERENCES

Salt handling and hypertension.

TLDR
Current knowledge of renal salt handling at the molecular level is outlined, and, given that Westernized societies consume more salt than is required for normal physiology, evidence that the lowering of salt intake can combat hypertension is examined.

Depressor Effect of Potassium Restriction on Blood Pressure of the Rat

  • S. C. FreedM. Friedman
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1951
Summary (1) Dietary restriction of potassium was found to lead to the occurrence of hypotension in the rat. (2) This depressor effect of potassium deprivation was prevented by simultaneous dietary…

Subtle acquired renal injury as a mechanism of salt-sensitive hypertension.

TLDR
This review provides an explanation of how initially subtle renal injury promotes a tendency toward hypertension, and how decreasing salt intake ameliorates the hypertension.

Chronic sodium chloride toxicity: the protective effect of added potassium chloride.

TLDR
There has a good basis for suspecting interrelations between dietary sodium and potassium in the context of chronic sodium chloride toxicity, and there has been a goodBased on preliminary findings, a broad spectrum of adverse events has been reported in patients with chronic Sodium chloride toxicity.

Potassium depletion exacerbates essential hypertension.

TLDR
Dietary potassium restriction increases blood pressure in patients with essential hypertension and both sodium retention and calcium depletion may contribute to the increase in blood pressure during potassium depletion.

Sodium and potassium in essential hypertension.

TLDR
It was concluded that two mechanisms probably operate in essential hypertension: in the early stages of the disease blood pressure is raised by an abnormal process related more closely to potassium than to sodium, and later a renal lesion develops later.

Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia.

TLDR
It is concluded that short-term potassium supplementation that ameliorates diuretic-induced hypokalemia may induce a significant fall in blood pressure.

Non‐modulating Hypertension A Subset of Sodium‐Sensitive Hypertension

TLDR
At least six different mechanisms have been proposed to account for a substantial change in blood pressure when a patient's salt intake is modified, and one of these subgroups—non-modulators is reviewed.

MECHANISM OF ANTIHYPERTENSIVE EFFECT OF DIETARY POTASSIUM IN EXPERIMENTAL VOLUME EXPANDED HYPERTENSION IN RATS

TLDR
Examination of the effect of increases in dietary potassium on the plasma level of endogenous DLS, myocardial and renal Na+, K+-ATPase (NKA) activities, BP, and renal excretory function in reduced renal mass (RRM)-salt hypertension in the rat shows that quadrupling the potassium in the diet prevents the BP increase in RRM rats and this is associated with diuresis/natriuresis and normalization of DLS.

Plasma sodium and hypertension.

TLDR
It is suggested that a small increase in plasma sodium may be part of the mechanisms whereby dietary salt increases the blood pressure.
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