Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter.

  title={Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter.},
  author={Ana M Pajor and Bruce A. Hirayama and Donald D. F. Loo},
  journal={The Journal of biological chemistry},
  volume={273 30},
The two-electrode voltage clamp was used to study the currents associated with transport of succinate by the cloned Na+/dicarboxylate cotransporter, NaDC-1, expressed in Xenopus oocytes. The presence of succinate induced inward currents which were dependent on the concentrations of succinate and sodium, and on the membrane potential. At -50 mV, the K0.5succinate was 180 microM and the K0.5Na+ was 19 mM. The Hill coefficient was 2.3, which is consistent with a transport stoichiometry of 3 Na+:1… CONTINUE READING


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