Sodium and lithium handling in the isolated hypertensive rat kidney.

@article{Firth1989SodiumAL,
  title={Sodium and lithium handling in the isolated hypertensive rat kidney.},
  author={John D. Firth and Anthony E. G. Raine and John G. G. Ledingham},
  journal={Clinical science},
  year={1989},
  volume={76 3},
  pages={335-41}
}
1. Isolated kidneys taken from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were perfused over a range of perfusion pressures. 2. Lithium clearance was used as an index of proximal tubule sodium handling. 3. When the perfusate contained an oncotic agent (albumin, 6.7 g/dl) the SHR kidneys performed differently from the WKY… CONTINUE READING