Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange.

@article{Knickelbein1983SodiumAC,
  title={Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange.},
  author={Roy G. Knickelbein and Peter S. Aronson and William L. Atherton and John W. Dobbins},
  journal={The American journal of physiology},
  year={1983},
  volume={245 4},
  pages={
          G504-10
        }
}
A series of experiments were performed to demonstrate the presence of and characterize the Na-H exchanger on rabbit ileal brush border with a vesicle preparation. An outwardly directed proton gradient (pH 5.5 inside, pH 7.5 outside) stimulated Na uptake, and a fourfold "overshoot" was observed. Conversely, an inwardly directed proton gradient (pH 7.5 inside, pH 5.5 outside) inhibited Na uptake. This stimulation/inhibition of Na uptake could not be accounted for by a proton diffusion potential… CONTINUE READING
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