Sodium-activated potassium channels are functionally coupled to persistent sodium currents.

@article{Hage2012SodiumactivatedPC,
  title={Sodium-activated potassium channels are functionally coupled to persistent sodium currents.},
  author={Travis Allen Hage and Lawrence Salkoff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 8},
  pages={2714-21}
}
We report a novel coupled system of sodium-activated potassium currents (I(KNa)) and persistent sodium currents (I(NaP)), the components of which are widely distributed throughout the brain. Its existence and importance has not been previously recognized. Although I(KNa) was known to exist in many cell types, the source of Na(+) which activates I(KNa) remained a mystery. We now show in single membrane patches generated from the somas of rat neurons that sodium influx through I(NaP) is… CONTINUE READING
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