Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease.

  title={Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease.},
  author={Etana Padan and Meytal Landau},
  journal={Metal ions in life sciences},
The transmembranal Na(+)/H(+) antiporters transport sodium (or several other monovalent cations) in exchange for H(+) across lipid bilayers in all kingdoms of life. They are critical in pH homeostasis of the cytoplasm and/or organelles. A particularly notable example is the SLC9 gene family, which encodes Na(+)/H(+) exchangers (NHEs) in many species from prokaryotes to eukaryotes. In humans, these proteins are associated with the pathophysiology of various diseases. Yet, the most extensively… CONTINUE READING