Sodium Oxybate: A Review of Its Use in Alcohol Withdrawal Syndrome and in the Maintenance of Abstinence in Alcohol Dependence
@article{Keating2013SodiumOA, title={Sodium Oxybate: A Review of Its Use in Alcohol Withdrawal Syndrome and in the Maintenance of Abstinence in Alcohol Dependence}, author={G. Keating}, journal={Clinical Drug Investigation}, year={2013}, volume={34}, pages={63-80} }
A liquid formulation of sodium oxybate (Alcover®), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence, as well as summarizing its pharmacological properties. Results of randomized controlled trials indicate… CONTINUE READING
Paper Mentions
Interventional Clinical Trial
The purpose of this study is to determine whether gamma-Hydroxybutyrate (GHB) has prosocial
and prosexual effects in healthy male participants, and to characterize these putative… Expand
Conditions | Autistic Disorder, Bipolar Disorder, Depressive Disorder, Major |
---|---|
Intervention | Drug |
53 Citations
A Brief Up-Date of the Use of Sodium Oxybate for the Treatment of Alcohol Use Disorder
- Medicine
- International journal of environmental research and public health
- 2016
- 17
- Highly Influenced
- PDF
Sodium oxybate plus nalmefene for the treatment of alcohol use disorder: A case series
- Medicine
- Journal of psychopharmacology
- 2016
- 4
- Highly Influenced
Clinical applications of sodium oxybate (GHB): from narcolepsy to alcohol withdrawal syndrome.
- Medicine
- European review for medical and pharmacological sciences
- 2015
- 25
- PDF
Sodium Oxybate in the Treatment of Alcohol Withdrawal Syndrome: A Randomized Double-Blind Comparative Study versus Oxazepam. The GATE 1 Trial
- Medicine
- CNS Drugs
- 2014
- 15
Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond.
- Medicine
- Journal of clinical and diagnostic research : JCDR
- 2015
- 54
- PDF
The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder
- Medicine
- Journal of psychopharmacology
- 2020
Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol
- Medicine
- Internal and Emergency Medicine
- 2018
- 13
- PDF
Pharmacotherapeutic management of acute alcohol withdrawal syndrome in critically Ill patients
- Medicine
- Expert opinion on pharmacotherapy
- 2020
References
SHOWING 1-10 OF 81 REFERENCES
Sodium oxybate in maintaining alcohol abstinence in alcoholic patients with and without psychiatric comorbidity
- Medicine
- European Neuropsychopharmacology
- 2011
- 21
- Highly Influential
Sodium oxybate in maintaining alcohol abstinence in alcoholic patients according to Lesch typologies: A pilot study
- Psychology, Medicine
- Journal of psychopharmacology
- 2014
- 12
- Highly Influential
Gamma-hydroxybutyric acid efficacy, potential abuse, and dependence in the treatment of alcohol addiction.
- Psychology, Medicine
- Alcohol
- 2000
- 74
New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications
- Medicine
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 2008
- 91
- Highly Influential
Substitution therapy for alcoholism: time for a reappraisal?
- Medicine
- Journal of psychopharmacology
- 2012
- 59
- Highly Influential
Gamma-hydroxybutyric acid (GHB) in the treatment of alcohol withdrawal syndrome: a randomized comparative study versus benzodiazepine.
- Psychology, Medicine
- Alcoholism, clinical and experimental research
- 1999
- 104
- Highly Influential
Gamma-hydroxybutyric acid versus naltrexone in maintaining alcohol abstinence: an open randomized comparative study.
- Medicine
- Drug and alcohol dependence
- 2003
- 71
- Highly Influential
Gamma-Hydroxybutyric Acid versus Clomethiazole for the Treatment of Alcohol Withdrawal Syndrome in a Medical Intensive Care Unit: An Open, Single-Center Randomized Study
- Medicine
- The American journal of drug and alcohol abuse
- 2009
- 15
Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses.
- Medicine
- The Cochrane database of systematic reviews
- 2010
- 118