Sodium Lauryl Sulfate-Induced Irritation in the Human Face: Regional and Age-Related Differences

@article{Marrakchi2006SodiumLS,
  title={Sodium Lauryl Sulfate-Induced Irritation in the Human Face: Regional and Age-Related Differences},
  author={Slaheddine Marrakchi and Howard I Maibach},
  journal={Skin Pharmacology and Physiology},
  year={2006},
  volume={19},
  pages={177 - 180}
}
The particular sensitivity of the human face to care products prompted us to study irritation induced by sodium lauryl sulfate (SLS) in its various regions. We examined regional and age-related differences, correlating basal transepidermal water loss (TEWL) and capacitance to SLS irritation. SLS (2% aq.) was applied under occlusion for 1 h to the forehead, cheek, nose, nasolabial and perioral areas, chin, neck and forearm to two groups of subjects – one with 10 subjects with an average age of… 

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References

SHOWING 1-10 OF 20 REFERENCES
Cutaneous sodium lauryl sulphate irritation potential: age and regional variability
TLDR
The data suggest that young adult skin is more sensitive to SLS than old skin and that SLS irritation varies considerably with respect to region, and objective TEWL measurements seem to be a better indicator of irritant susceptibility, especially in the elderly, than clinical evaluation by visual scoring.
Monitoring of skin response to sodium lauryl sulphate: clinical scores versus bioengineering methods.
TLDR
The profile of erythema scores over time differed between neck and forearm, but the delta CBFV readings with the laser Doppler instrument did not detect significant site-time interactions, and roughness and capacitance readings showed significant differences between sites,but the profile over time was similar in both locations.
Baseline transepidermal water loss (TEWL) as a prediction of susceptibility to sodium lauryl sulphate
TLDR
The baseline TEWL level (TEWL1) might be a reliable indication of an individual's susceptibility to weak irritants and the influence of such factors as history of mucosal atopy, history of sensitivity to soap, dry skin, skin type, sex and age was negligible.
Regional variation of nonimmunologic contact urticaria. Functional map of the human face.
  • D. Shriner, H. Maibach
  • Medicine
    Skin pharmacology : the official journal of the Skin Pharmacology Society
  • 1996
TLDR
This information provides a basis to further study the frequent poorly understood intolerance of the face to topical formulation and a significant correlation was noted between stratum corneum hydration and irritation.
Site variations in susceptibility to SLS
TLDR
The results show that it is essential to point out the exact position of the test area at the volar forearm in study reports and to randomize the irritation areas at thevolar forearm if different treatments are to be compared.
Seasonal variation of skin resistance to irritants
TLDR
A decreased hydration state of the epidermis of unexposed skin was found during the winter, and it is believed this to be responsible for the increased susceptibility to SLS during this season.
Functional map and age‐related differences in the human face: nonimmunologic contact urticaria induced by hexyl nicotinate
TLDR
The regional and the age‐related variability of the stratum corneum turnover and the skin reactions to HN is demonstrated to help explain some aspects of the cutaneous intolerance in skin care of the face.
Irritant effect of a model surfactant on the human vulva and forearm. Age-related differences.
TLDR
Age-related differences in irritant reaction were more apparent in low-grade irritant dermatitis induced by low concentrations of SLS than in intense reactions to higher SLS concentrations.
The use of transepidermal water loss to measure and predict the irritation response to surfactants
TLDR
A high baseline TEWL value may be predictive of a high susceptibility to soap irritation as measured by the chamber test, and there was also a statistically significant correlation between TewL values obtained on the untreated skin at Time 0 and the five‐day average irritation score for these two cleansing products.
...
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