Sodium Dynamics Underlying Burst Firing and Putative Mechanisms for the Regulation of the Firing Pattern in Midbrain Dopamine Neurons: A Computational Approach

@article{Canavier1999SodiumDU,
  title={Sodium Dynamics Underlying Burst Firing and Putative Mechanisms for the Regulation of the Firing Pattern in Midbrain Dopamine Neurons: A Computational Approach},
  author={Carmen C. Canavier},
  journal={Journal of Computational Neuroscience},
  year={1999},
  volume={6},
  pages={49-69}
}
A physiologically based multicompartmental computational model of a midbrain dopamine (DA) neuron, calibrated using data from the literature, was developed and used to test the hypothesis that sodium dynamics drive the generation of a slow oscillation postulated to underlie NMDA-evoked bursting activity in a slice preparation. The full compartmental model was reduced to three compartments and ultimately to two variables, while retaining the biophysical interpretation of all parameters. A phase… CONTINUE READING

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