Sodium Channel β Subunits: Anything but Auxiliary

@article{Isom2001SodiumC,
  title={Sodium Channel β Subunits: Anything but Auxiliary},
  author={L. Isom},
  journal={The Neuroscientist},
  year={2001},
  volume={7},
  pages={42 - 54}
}
  • L. Isom
  • Published 2001
  • Biology
  • The Neuroscientist
  • Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and propagation of action potentials in excitable cells such as central and peripheral neurons, cardiac and skeletal muscle myocytes, and neuroendocrine cells. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The α subunits form a gene family with at least 10 members. Mutations in α subunit genes have been linked to paroxysmal disorders such… CONTINUE READING
    296 Citations

    Figures from this paper.

    The role of sodium channels in cell adhesion.
    • L. Isom
    • Medicine
    • Frontiers in bioscience : a journal and virtual library
    • 2002
    • 102
    • PDF
    The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.
    • 76
    Mice Lacking Sodium Channel β1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture
    • 232
    • PDF
    Voltage-gated sodium channels: mutations, channelopathies and targets.
    • 56
    Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes.
    • 33
    Regulatory Role of Voltage-Gated Na+ Channel β Subunits in Sensory Neurons
    • 32
    • Highly Influenced
    • PDF
    Developmental and Regulatory Functions of Na(+) Channel Non-pore-forming β Subunits.
    • 9

    References

    SHOWING 1-10 OF 61 REFERENCES
    Tenascin-R Is a Functional Modulator of Sodium Channel β Subunits*
    • 203
    • PDF
    beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.
    • 291
    • PDF