Sodium Channel β Subunits: Anything but Auxiliary

  title={Sodium Channel β Subunits: Anything but Auxiliary},
  author={L. Isom},
  journal={The Neuroscientist},
  pages={42 - 54}
  • L. Isom
  • Published 2001
  • Biology
  • The Neuroscientist
  • Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and propagation of action potentials in excitable cells such as central and peripheral neurons, cardiac and skeletal muscle myocytes, and neuroendocrine cells. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The α subunits form a gene family with at least 10 members. Mutations in α subunit genes have been linked to paroxysmal disorders such… CONTINUE READING
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