Sodium Channel β Subunits: Anything but Auxiliary

@article{Isom2001SodiumC,
  title={Sodium Channel $\beta$ Subunits: Anything but Auxiliary},
  author={Lori L. Isom},
  journal={The Neuroscientist},
  year={2001},
  volume={7},
  pages={42 - 54}
}
  • L. Isom
  • Published 1 February 2001
  • Biology
  • The Neuroscientist
Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and propagation of action potentials in excitable cells such as central and peripheral neurons, cardiac and skeletal muscle myocytes, and neuroendocrine cells. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The α subunits form a gene family with at least 10 members. Mutations in α subunit genes have been linked to paroxysmal disorders such… Expand

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TLDR
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Developmental and Regulatory Functions of Na(+) Channel Non-pore-forming β Subunits.
TLDR
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TLDR
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Voltage-gated Na+ channels: Potential for β subunits as therapeutic targets
Background: Voltage gated Na+ channels (VGSCs) contain a pore-forming α subunit and one or more β subunits. VGSCs are involved in a wide variety of pathophysiologies, including epilepsy, cardiacExpand
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