Sodium – lithium countertransport and the Gly 460 → Trp α-adducin polymorphism in essential hypertension

@inproceedings{MEAD2005SodiumL,
  title={Sodium – lithium countertransport and the Gly 460 → Trp α-adducin polymorphism in essential hypertension},
  author={Paul. A. MEAD and John. N. HARVEY and Peter. A. RUTHERFORD and Helen F Leitch and Trevor. H. THOMAS},
  year={2005}
}
A polymorphism of the α-subunit of adducin, Gly460 → Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The α-adducin Gly460 → Trp polymorphism was determined in 242 NC (normal controls) and 73 patients with EH and was related to the membrane ion transport marker in EH, erythrocyte Na/LiCT (sodium–lithium countertransport), in a subgroup of these subjects. The Km for external sodium was lower in patients with EH than NC. The Km of the Trp allele was… CONTINUE READING

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