Sodium‐dependent high‐affinity uptake of taurine in cultured cerebellar granule cells and astrocytes

@article{Holopainen1987SodiumdependentHU,
  title={Sodium‐dependent high‐affinity uptake of taurine in cultured cerebellar granule cells and astrocytes},
  author={I. Holopainen and O. Malminen and P. Kontro},
  journal={Journal of Neuroscience Research},
  year={1987},
  volume={18}
}
Taurine uptake in cultured cerebellar granule cells and astrocytes consisted of a saturable high‐affinity component and nonsaturable diffusion. The transport constant (Km) was significantly lower and the maximal velocity (V) higher in granule cells than in astrocytes. The uptakes were strictly sodium dependent and also moderately decreased in potassium‐free medium. The specificity profile of taurine uptake was similar in both cell types, hypotaurine β‐alanine, and guanidinoethanesulphonic acid… Expand
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