Sodium/calcium exchange: its physiological implications.

@article{Blaustein1999SodiumcalciumEI,
  title={Sodium/calcium exchange: its physiological implications.},
  author={M. Blaustein and W. Lederer},
  journal={Physiological reviews},
  year={1999},
  volume={79 3},
  pages={
          763-854
        }
}
The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As a reversible transporter, it also mediates Ca2+ entry in parallel with various ion channels. The energy for net Ca2+ transport by the Na+/Ca2+ exchanger and its direction depend on the Na+, Ca2+, and K+ gradients across the PM, the membrane potential, and the transport stoichiometry. In most cells, three Na… Expand
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