Sodium/calcium exchange: its physiological implications.

  title={Sodium/calcium exchange: its physiological implications.},
  author={M. Blaustein and W. J. Lederer},
  journal={Physiological reviews},
  volume={79 3},
  • M. Blaustein, W. J. Lederer
  • Published 1999
  • Physics, Medicine
  • Physiological reviews
  • The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As a reversible transporter, it also mediates Ca2+ entry in parallel with various ion channels. The energy for net Ca2+ transport by the Na+/Ca2+ exchanger and its direction depend on the Na+, Ca2+, and K+ gradients across the PM, the membrane potential, and the transport stoichiometry. In most cells, three Na… CONTINUE READING
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