Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.

@article{Ivannikov2015Sod1GA,
  title={Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.},
  author={Maxim V. Ivannikov and Holly van Remmen},
  journal={Free radical biology & medicine},
  year={2015},
  volume={84},
  pages={
          254-262
        }
}
Reactive oxygen species (ROS) are believed to be important mediators of muscle atrophy and weakness in aging and many degenerative conditions. However, the mechanisms and physiological processes specifically affected by elevated ROS in neuromuscular units that contribute to muscle weakness during aging are not well defined. Here we investigate the effects of chronic oxidative stress on neurotransmission and excitation-contraction (EC) coupling mechanisms in the levator auris longus (LAL) muscle… CONTINUE READING
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Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia?

Simona Damiano, Espedita Muscariello, +3 authors Mariarosaria Santillo
  • International journal of molecular sciences
  • 2019
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