Socioeconomic status in systemic lupus erythematosus

  title={Socioeconomic status in systemic lupus erythematosus},
  author={Sangeeta D. Sule and Michelle A. Petri},
  pages={720 - 723}
Our understanding of the biological pathogenesis of systemic lupus erythematosus (SLE) is rapidly expanding. Although biologic research is vital, studies that address the importance of socioeconomic factors that contribute to the causation of the outcome of SLE are necessary to understand the full scope of the disease. Studies of social factors in SLE usually include ethnicity, gender and socioeconomic status (SES) as categorical variables. One hypothesis is that these variables exert their… 

Systemic lupus erythematosus.

Systemic Lupus Erythematosus: A Therapeutic Update

Advancements in the understanding of molecular and cellular mechanisms involved in the pathogenesis have resulted in development of novel therapies and immunomodulatory drugs developed for other diseases are being investigated for use in specific manifestations of lupus.

An update on mortality in systemic lupus erythematosus.

Survival rates for lupus patients have improved greatly with the ability to treat disease-specific manifestations and infections and to lessen the impact of comorbid conditions, but disparities in mortality rates still exist based on ethnicity, socioeconomic status, age, and gender.

Asian ethnicity in systemic lupus erythematosus: an Australian perspective

This review focuses on the evidence of disparities between SLE patients of Asian and Caucasian descent, the two predominant ethnic groups affected by SLE in the Australian context.

Socioeconomic status and organ damage in Mexican systemic lupus erythematosus women

In the adjusted multivariate analysis, low monthly income ( < $300) was associated with organ damage in Mexican SLE patients, suggesting that low income may be associated with organs damage in patients with SLE.

What can epidemiology tell us about systemic lupus erythematosus?

The epidemiologic evidence for several putative risk factors including cigarette smoke, hormonal and reproductive factors, environmental silica and infectious exposures, as well as many yet to be identified are outlined.

Systemic Lupus Erythematosus

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  • Medicine
    Annals of the New York Academy of Sciences
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Abstract:  This review documents the remarkable progress systemic lupus erythematosus (SLE) has made in the past 40 years especially in Asia. It provides a kaleidoscope in terms of prevalence, ethnic

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Two novel SLE candidate genes contributing to SLE susceptibility in several populations are identified as well as shown that a number of previously identified Sle susceptibility genes also contribute to risk in the Finnish population.

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Two distinct disease activity patterns are identifiable in juvenile systemic lupus erythematosus: chronic active and long quiescence, and suppression of disease with early aggressive treatment may decrease the rate of progression.



Racial group, socioeconomic status, and the development of persistent proteinuria in systemic lupus erythematosus

Differing socioeconomic factors do not explain the increased frequency of lupus nephritis in Afro-Caribbean patients with SLE, but rather there are important genetic or other host differences.

Morbidity of systemic lupus erythematosus: role of race and socioeconomic status

The data fail to support an independent association of black race with morbidity in SLE; rather, they suggest that noncompliance (as measured by physician global assessment) and type of medical insurance are important factors in morbidity.

Systemic lupus erythematosus.

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  • Medicine
    Rheumatic diseases clinics of North America
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Analysis and genetic epidemiologic studies suggest a multifactorial etiology of SLE and results support a polygenic mode of inheritance including important roles for an autosomal dominant "autoimmune" gene and female sex hormones.

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It is suggested that race is under-recognized as a factor influencing the clinical heterogeneity of SLE, and blacks were more likely than whites to have had psychosis, serositis, and urinary cellular casts, and less likely to haveHad sicca syndrome.

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It is found that both American black race and increasing age at SLE onset independently worsened the probability of survival, and thrombocytopenia emerged as the only independent risk factor for a worse prognosis in SLE.

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Hispanic and African-American ethnicities and antibodies were shown to be signi” cant predictors of the occurrence of LN, and Sociodemographic,clinical and immunologic/immunogenetic factors seem to be predictive of its occurrence.

Systemic lupus erythematosus in three ethnic groups. XIV. Poverty, wealth, and their influence on disease activity.

Investigating the impact of wealth in the multiethnic LUMINA cohort of patients with systemic lupus erythematosus found wealth does not appear to have an additional predictive value, over and above traditional measures of socioeconomic status, in SLE disease activity.

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In a large prospective cohort of patients with SLE, the Kaplan-Meier method was used to estimate survival probabilities of SLE patients over time since diagnosis and the predictors of survival in SLE using Cox proportional hazards models were analyzed.

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Genetic factors appear to be more important than SES in explaining the ethnic disparities in the occurrence of renal involvement in a large multiethnic SLE cohort.