Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

  title={Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia},
  author={Katrine Fabricius and Bj{\"o}rn Steiniger-Brach and Lone Helboe and Anders Fink-Jensen and Gitta W{\"o}rtwein},
  journal={International Journal of Developmental Neuroscience},
Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and… CONTINUE READING


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