Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis.

@article{Powell2013SocialSU,
  title={Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis.},
  author={Nicole D. Powell and Erica K. Sloan and Michael T. Bailey and Jesusa Arevalo and Gregory E Miller and Edith Chen and Michael S. Kobor and Brenda F. Reader and John F Sheridan and Steve W. Cole},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 41},
  pages={16574-9}
}
Across a variety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian immune cells have been found to show a conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes. The present study examines whether such effects might stem in part from the selective up-regulation of a subpopulation of immature proinflammatory monocytes (Ly-6c(high) in mice, CD16(-) in humans) within the circulating leukocyte pool… CONTINUE READING
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Transcriptional modulation of human leukocytes by cognitive - behavioral stress management in women undergoing treatment for breast can

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