Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.

@article{Boyson2014SocialSA,
  title={Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.},
  author={Christopher O. Boyson and Elizabeth Nicole Holly and Akiko Shimamoto and Lucas Albrechet-Souza and Lindsay A. Weiner and Joseph F. Debold and Klaus A Miczek},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 19},
  pages={
          6659-67
        }
}
The nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable interest. Intermittent social defeat stress induces both locomotor and dopaminergic cross-sensitization to cocaine, as well as escalated cocaine self-administration. The current study examines the role of corticotropin releasing factor receptor subtypes 1 and 2 (CRFR1, CRFR2) within the ventral tegmental area (VTA) during social defeat stress. This study investigated whether injecting… CONTINUE READING
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Episodic Social Stress-Escalated Cocaine Self-Administration: Role of Phasic and Tonic Corticotropin Releasing Factor in the Anterior and Posterior Ventral Tegmental Area.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2016
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