Social stress alters splenocyte phenotype and function.

  title={Social stress alters splenocyte phenotype and function.},
  author={Ronit Avitsur and Jennifer L. Stark and Firdaus S. Dhabhar and John F Sheridan},
  journal={Journal of neuroimmunology},
  volume={132 1-2},
Social stress of group-housed male mice induced a state of functional glucocorticoid (GC) resistance in splenocytes. The following studies examined the effects of paired-fighting (PF) stress on immune cell distribution and function in spleens of male mice. Following six daily PF stress sessions, splenic monocytes and neutrophils increased and lymphocytes decreased. PF also altered the distribution of CD62L and CD11b positive monocytes. Additionally, PF augmented proliferation and lowered the… CONTINUE READING