Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers

@article{Matuskey2019SocialSA,
  title={Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers},
  author={David Matuskey and Mark Dias and Mika Naganawa and Brian P. Pittman and Shannan Henry and Songye Li and Hong Gao and Jim R Ropchan and Nabeel B. Nabulsi and Richard E. Carson and Yiyun Huang},
  journal={Neuropsychopharmacology},
  year={2019},
  pages={1-6}
}
Kappa opioid receptors (KORs) have been characterized as an aversive system in the brain and implicated in social behavior in preclinical models. This work investigated the effect of social status on the KOR system in humans using positron emission tomography (PET) imaging with the novel KOR agonist radiotracer [11C]EKAP. Eighteen healthy participants (mean age 41.2 ± 9.3) completed the Barratt Simplified Measure of Social Status (BSMSS), an MRI and an [11C]EKAP PET scan on the High Resolution… 
Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics
TLDR
The development and evaluation of 11C-EKAP is reported, successfully developed, as a KOR agonist tracer with dual attractive imaging properties of fast uptake kinetics and high specific binding in vivo.
Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography.
TLDR
The potential of KOR PET to detect changes in endogenous dynorphin in the human brain, to elucidate neural mechanisms and offer critical insight into disease-modifying therapeutics is discussed, and comments on other translational neuroimaging modalities such as MRI that could be used to study KOR-dynorphin tone in the living human brain are concluded.
Evaluation of Specific Binding of [11C]RTI-97 to Kappa Opioid Receptor by Autoradiography and PET Imaging in Rat.
TLDR
The overall results showed a heterogeneous repartition and specific KOR binding of [ 11C]RTI-97 in brain and a high and specific accumulation of [11C] RTI- 97 in pituitary in accordance with KOR expression.
A Survey of Molecular Imaging of Opioid Receptors
TLDR
There is scant documentation of δ-, κ-, or ORL1 receptors in healthy human brain or in neurological and psychiatric disorders; here, clinical PET research must catch up with recent progress in radiopharmaceutical chemistry.
Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders
TLDR
Current molecular imaging literature is reviewed to assess how genetic variations in the opioid and dopamine systems affect function in the brain’s reward, cognition, and stress pathways, potentially resulting in vulnerabilities to opioid use disorder.
Endogenous opiates and behavior: 2019
Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry.
TLDR
Further work elucidating the role of the DYN/KOR system in controlling cortical information processing and associated behaviors will be of importance to increasing the understanding of principles underlying neuropeptide modulation of cortical circuits, mechanisms underlying sensation and perception, motivated and emotional behavior, and cognition.
Pediatric Cancer Survivorship: Impact Upon Hair Cortisol Concentration and Family Functioning
TLDR
Preliminary evidence is provided for a relationship between a stress biomarker, child CORTHAIR, and family functioning among pediatric cancer survivors and controls.
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