Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38.

@article{Higashida2012SocialMA,
  title={Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38.},
  author={Haruhiro Higashida and Shigeru Yokoyama and Jian-Jun Huang and Li Liu and Wen-jie Ma and Shirin Akther and Chiharu Higashida and Mitsuru Kikuchi and Yoshio Minabe and Toshio Munesue},
  journal={Neurochemistry international},
  year={2012},
  volume={61 6},
  pages={828-38}
}
Previously, we demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition. When CD38 was disrupted, social amnesia was observed in Cd38 knockout mice. The autism spectrum disorders (ASDs), characterized by defects in reciprocal social interaction and communication, occur either sporadically or in a familial pattern. However, the etiology… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
25 Citations
96 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 96 references

Similar Papers

Loading similar papers…