Corpus ID: 8764620

Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function.

@article{Serra2006SocialII,
  title={Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function.},
  author={M. Serra and M. Mostallino and G. Talani and M. G. Pisu and M. Carta and M. Mura and I. Floris and E. Maciocco and E. Sanna and G. Biggio},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 1},
  pages={
          122-33
        }
}
  • M. Serra, M. Mostallino, +7 authors G. Biggio
  • Published 2006
  • Medicine
  • Journal of neurochemistry
  • Previously we have demonstrated that social isolation of rats reduces both the cerebrocortical and plasma concentrations of 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and potentiates the positive effects of acute ethanol administration on the concentrations of this neurosteroid. We now show that the ethanol-induced increase in 3alpha,5alpha-TH PROG is more pronounced in the brain than in the plasma of isolated rats. The ability of ethanol to inhibit isoniazid-induced… CONTINUE READING
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