Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

@article{Goldberg2012SocialEA,
  title={Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease},
  author={Natalie R. S. Goldberg and Victoria Fields and Lacey R. Pflibsen and Michael F. Salvatore and Charles K. Meshul},
  journal={Neurobiology of Disease},
  year={2012},
  volume={45},
  pages={1051-1067}
}

Figures and Tables from this paper

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The results show progressive behavioral decline in a cued response task with increasing weekly doses of MPTP, and it is proposed that the behavioral decline following MPTP treatment may be associated with a change not only in cortical–cortical glutamate function but also in striatal DA and glutamate input.
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