Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood

@article{McDade2017SocialAP,
  title={Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood},
  author={T. McDade and Calen P Ryan and Meaghan J. Jones and J. MacIsaac and Alexander M. Morin and Jess M Meyer and J. Borja and G. Miller and M. Kobor and C. Kuzawa},
  journal={Proceedings of the National Academy of Sciences},
  year={2017},
  volume={114},
  pages={7611 - 7616}
}
Significance Environments in infancy and childhood influence levels of inflammation in adulthood—an important risk factor for multiple diseases of aging—but the underlying biological mechanisms remain uncertain. Using data from a unique cohort study in the Philippines with a lifetime of information on each participant, we provide evidence that nutritional, microbial, and psychosocial exposures in infancy and childhood predict adult levels of DNA methylation—biochemical marks on the genome that… Expand
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