Social Isolation Stress-Induced Fear Memory Deficit is Mediated by Down-Regulated Neuro-Signaling System and Egr-1 Expression in the Brain

@article{Okada2014SocialIS,
  title={Social Isolation Stress-Induced Fear Memory Deficit is Mediated by Down-Regulated Neuro-Signaling System and Egr-1 Expression in the Brain},
  author={Ryo Okada and Kinzo Matsumoto and Ryohei Tsushima and Hironori Fujiwara and Koichi Tsuneyama},
  journal={Neurochemical Research},
  year={2014},
  volume={39},
  pages={875-882}
}
  • Ryo Okada, Kinzo Matsumoto, +2 authors Koichi Tsuneyama
  • Published in Neurochemical Research 2014
  • Biology, Medicine
  • We previously reported that social isolation (SI) rearing of rodents not only elicits a variety of behavioral abnormalities including attention deficit hyperactivity disorder-like behaviors, but also impairs fear memory in mice. This study aimed to clarify a putative mechanism underlying SI-induced conditioned fear memory deficit. Mice were group-housed (GH) or socially isolated for 2 weeks or more before the experiments. SI animals acquired contextual and auditory fear memory elucidated at 90… CONTINUE READING

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