Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress

@inproceedings{Ma2011SocialIA,
  title={Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress},
  author={Xian-cang Ma and Dong Jiang and Wen-hui Jiang and Fen Wang and Min Jia and Jin Yang Wu and Kenji Hashimoto and Yong-hui Dang and Cheng-ge Gao},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as major depression. It is also well known that social isolation in male mice results in aggressive behavior. However, it is not known how social isolation-induced aggression affects anxiety and depressive-like behavior in isolated male mice subjected to unpredictable chronic mild stress (CMS), an animal model of depression. METHODOLOGY/PRINCIPAL… CONTINUE READING