Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning

@article{Whitaker2013SocialDE,
  title={Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning},
  author={Leslie R Whitaker and Mickael Degoulet and Hitoshi Morikawa},
  journal={Neuron},
  year={2013},
  volume={77},
  pages={335-345}
}
Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life, particularly during adolescence, increase addiction vulnerability. Social isolation in rodents has been used extensively to model the effects of deficient social experience, yet its impact on learning and memory processes underlying addiction remains elusive. Here, we show that social isolation of rats during a critical period of adolescence (postnatal days 21-42) enhances long-term potentiation of… CONTINUE READING
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