Social Defeat Stress-Induced Behavioral Responses are Mediated by the Endogenous Kappa Opioid System

@article{Mclaughlin2006SocialDS,
  title={Social Defeat Stress-Induced Behavioral Responses are Mediated by the Endogenous Kappa Opioid System},
  author={J Patrick Mclaughlin and Shuang Shuang Li and Joseph Valdez and Theodore A Chavkin and Charles Chavkin},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={1241-1248}
}
Previous studies have demonstrated that repeated forced-swim stress-induced behaviors (including analgesia, immobility, and increased drug reward) were mediated by the release of endogenous prodynorphin-derived opioid peptides and subsequent activation of the kappa opioid receptor (KOR). We tested the generality of these effects using a different type of stressful situation: repeated social defeat. C57Bl/6 mice subjected to social defeat stress (SDS) over 3 days showed a characteristic stress… CONTINUE READING

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CocaineIs related toDrug abuse
Since both stress and the kappa opioid system can modulate the response to drugs of abuse , we tested the effects of SDS on cocaine - conditioned place preference ( CPP ) .
Since both stress and the kappa opioid system can modulate the response to drugs of abuse , we tested the effects of SDS on cocaine - conditioned place preference ( CPP ) .
Since both stress and the kappa opioid system can modulate the response to drugs of abuse , we tested the effects of SDS on cocaine - conditioned place preference ( CPP ) .
Drug abuseIs related toCocaine
Since both stress and the kappa opioid system can modulate the response to drugs of abuse , we tested the effects of SDS on cocaine - conditioned place preference ( CPP ) .
Previous studies have demonstrated that repeated forced - swim stress - induced behaviors ( including analgesia , immobility , and increased drug reward ) were mediated by the release of endogenous prodynorphin - derived opioid peptides and subsequent activation of the kappa opioid receptor ( KOR ) .
Previous studies have demonstrated that repeated forced - swim stress - induced behaviors ( including analgesia , immobility , and increased drug reward ) were mediated by the release of endogenous prodynorphin - derived opioid peptides and subsequent activation of the kappa opioid receptor ( KOR ) .
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