Sobetirome prodrug esters with enhanced blood-brain barrier permeability.

  title={Sobetirome prodrug esters with enhanced blood-brain barrier permeability.},
  author={Andrew T Placzek and Skylar J Ferrara and Meredith D Hartley and Hannah S Sanford-Crane and J Matthew Meinig and Thomas S. Scanlan},
  journal={Bioorganic & medicinal chemistry},
  volume={24 22},
There is currently great interest in developing drugs that stimulate myelin repair for use in demyelinating diseases such as multiple sclerosis. Thyroid hormone plays a key role in stimulating myelination during development and also controls the expression of important genes involved in myelin repair in adults. Because endogenous thyroid hormone in excess… CONTINUE READING