Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.

  title={Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.},
  author={Tomohiko Matsuzawa and Yasuko Fujita and Hideki Tohda and Kaoru Takegawa},
  journal={Eukaryotic cell},
  volume={11 2},
The function of two fission yeast genes, SPCC74.03c/ssp2(+) and SPAC23H4.02/ppk9(+), encoding an Snf1-like protein kinase were investigated. Deletion of ssp2(+) caused a partial defect in glucose derepression of inv1(+), fbp1(+), and gld1(+) and in assimilation of sucrose and glycerol, while a mutation in ppk9(+) had no apparent effect. Scr1, a transcription factor involved in glucose repression, localized to the nucleus under glucose-rich conditions and to the cytoplasm during glucose… CONTINUE READING
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