The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase
- BiologyFrontiers in Genetics
It is found that knockdown of SETDB1 impaired cell proliferation, led to an increase in reactive oxygen species (ROS) level through NADPH oxidase, and Setdb1 deficiency activated ROS downstream signaling pathways, including JNK and p38 MAPK, which possibly contributed to SSC apoptosis.
Critical physiological and pathological functions of Forkhead Box O tumor suppressors
A better understanding of the structure and critical functions of FOXO transcription factors and tumor suppressors may contribute to the development of novel therapies for cancer and other diseases.
Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a
- BiologyIntrinsically disordered proteins
The FOXO3a IDRs are emerging as key mediators of diverse regulatory processes, and represent an important target for the future development of therapeutics for FOXO 3a-related diseases.
The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function
- BiologyInternational journal of molecular sciences
The current literature of FoxOs is reviewed for their roles in bone cells, focusing on helping researchers to develop new therapeutic approaches and prevent or treat the related bone diseases.
β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer
- BiologyCell Death & Differentiation
It is found that FOXN2 binds to and is ubiquitinated by β-Trcp ubiquitin ligase and RSK2 kinase for degradation, and it is demonstrated that the Ser365 and Ser369 sites in a conserved DSGYAS motif are critical for the degradation of FOXN1.
Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions
- BiologyFront. Physiol.
A functional interplay between Fkh1/Fkh2 and Sir2 is shown suggesting a novel mechanism of cell cycle repression suggesting a protective response against stress could be directly coordinated by Fkh 1 and Fkh2.
The Fox genes in the liver: from organogenesis to functional integration.
- BiologyPhysiological reviews
This work discusses the biochemical and genetic roles of Foxa, Foxl1, Foxm1, and Foxo, as these have been shown to regulate many processes throughout the life of the organ, controlling both formation and function of the liver.
A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis
- BiologyFront. Cell Dev. Biol.
The role of FOXI3 in embryogenesis and bone development is summarized and its potential involvement in cancer progression is discussed with a focus on the bone metastasis.
Forkhead Transcription Factors in Health and Disease.
- BiologyTrends in genetics : TIG
Foxl3, a Target of miR-9, Stimulates Spermatogenesis in Spermatogonia During Natural Sex Change in Monopterus albus.
Foxl3 and miR-9 may be involved in physiological processes that promote oocyte degeneration in the ovotestis and stimulating spermatogenesis in sperMatogonia in M albus.
SHOWING 1-9 OF 9 REFERENCES
Forkhead transcription factors in immunology
- BiologyCellular and Molecular Life Sciences CMLS
The forkhead genes promise insight into the mechanisms of immunoregulation in several immune cell lineages, and their dysregulation likely contributes to the pathogenesis of several immunological disorders, suggesting that their study will lead to the development of novel therapeutic agents.
In control of biology: of mice, men and Foxes.
- BiologyThe Biochemical journal
This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans.
Forkhead transcription factors: key players in development and metabolism.
- BiologyDevelopmental biology
Forkhead proteins are not among the largest transcription factor families, but display a remarkable functional diversity and are involved in a wide variety of biological processes.
Human FOX gene family
- Int . J . Oncol .
Human FOX gene family
- Int. J. Oncol
Mouse Genome Database (MGD), Mouse Genome Informatics Website, The Jackson Laboratory, Bar Harbor, Maine
- Biochem. J. 397,
Ingenuity Pathways Analysis
- Ingenuity Pathways Analysis