SnapShot: Hematopoiesis

@article{Orkin2008SnapShotH,
  title={SnapShot: Hematopoiesis},
  author={Stuart H. Orkin and Leonard I. Zon},
  journal={Cell},
  year={2008},
  volume={132},
  pages={712.e1-712.e2}
}
Exploring the role of GATA2 in normal and malignant haematopoiesis
TLDR
Gata2, a zinc finger TF expressed in the haematopoietic system, is essential for the generation and survival of HSCs in development, however the requirement for Gata2 in adult HSCS is less clear.
A systems biological perspective on complex human diseases: uncovering hidden relations via multi-scale network analyses
TLDR
Algorithms capable of analyzing complex systems via multi-scale network analyses and experimentally testable hypotheses about potential causative explanations represent pieces in the puzzle of understanding complex diseases and strategies to solve it, and consequently they allow narrowing down the gap between genotype and phenotype.
Critical roles for the co-repressor, Rcor1, in lineage determination
................................................................................................................................... 1 CHAPTER 1: Introduction
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.
TLDR
It is demonstrated that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor.
hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 low Mutation in Mice
TLDR
The ability of hGATA1 to rescue the hematopoietic functions of the bone marrow of the double mutants was confirmed by the observation that these mice survive well splenectomy and did not develop myelofibrosis with age.
Effects of temperature and photoperiod on rainbow trout (Oncorhynchus mykiss) smoltification and haematopoiesis
TLDR
This poster presents a probabilistic procedure for identifying the phytochemical properties of woodpecker eggs that have an important role in the establishment and consumption of fish and shellfish.
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia
TLDR
These studies provided significant insights into LMO2/LDB1 macromolecular protein complex assembly and stability, which has implications for understanding its role in blood cell formation and for therapeutically targeting this complex in human leukemias.
Physiological and metabolic approach of plastic additive effects: Immune cells responses.
TLDR
This review highlights data evidencing mitochondrial dysfunctions triggered by plasticizing toxic action, which can lead to immunosuppression, and points out critically the role of some nuclear and membrane receptors as key players in the action of plasticizers on cells possess immune function.
Identification and Analysis of Mouse Erythroid Progenitor Cells.
TLDR
The range of different technical approaches that are used to identify and quantify erythroid progenitors are discussed, with particular focus on the mouse as a model system.
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