SnapShot: Hematopoiesis

  title={SnapShot: Hematopoiesis},
  author={Stuart H. Orkin and Leonard I. Zon},
Exploring the role of GATA2 in normal and malignant haematopoiesis
Gata2, a zinc finger TF expressed in the haematopoietic system, is essential for the generation and survival of HSCs in development, however the requirement for Gata2 in adult HSCS is less clear.
A systems biological perspective on complex human diseases: uncovering hidden relations via multi-scale network analyses
Algorithms capable of analyzing complex systems via multi-scale network analyses and experimentally testable hypotheses about potential causative explanations represent pieces in the puzzle of understanding complex diseases and strategies to solve it, and consequently they allow narrowing down the gap between genotype and phenotype.
Critical roles for the co-repressor, Rcor1, in lineage determination
................................................................................................................................... 1 CHAPTER 1: Introduction
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.
It is demonstrated that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor.
hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 low Mutation in Mice
The ability of hGATA1 to rescue the hematopoietic functions of the bone marrow of the double mutants was confirmed by the observation that these mice survive well splenectomy and did not develop myelofibrosis with age.
Effects of temperature and photoperiod on rainbow trout (Oncorhynchus mykiss) smoltification and haematopoiesis
This poster presents a probabilistic procedure for identifying the phytochemical properties of woodpecker eggs that have an important role in the establishment and consumption of fish and shellfish.
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia
These studies provided significant insights into LMO2/LDB1 macromolecular protein complex assembly and stability, which has implications for understanding its role in blood cell formation and for therapeutically targeting this complex in human leukemias.
Physiological and metabolic approach of plastic additive effects: Immune cells responses.
This review highlights data evidencing mitochondrial dysfunctions triggered by plasticizing toxic action, which can lead to immunosuppression, and points out critically the role of some nuclear and membrane receptors as key players in the action of plasticizers on cells possess immune function.
Identification and Analysis of Mouse Erythroid Progenitor Cells.
The range of different technical approaches that are used to identify and quantify erythroid progenitors are discussed, with particular focus on the mouse as a model system.


Diversification of haematopoietic stem cells to specific lineages
  • S. Orkin
  • Biology, Medicine
    Nature Reviews Genetics
  • 2000
Recent findings not only indicate how this may be achieved but also show the extraordinary plasticity of tissue stem cells in vivo.
Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals.
An additional mechanism, still not fully defined, is required just prior to T cell receptor-mediated selection to end plasticity and make T lineage commitment irreversible.
The transcriptional regulation of B cell lineage commitment.
This review focuses on recent studies that have revealed that instead of a simple transcriptional hierarchy, efficient B cell commitment and differentiation requires the combinatorial activity of multiple transcription factors in a complex gene regulatory network.
Transcriptional control of erythropoiesis: emerging mechanisms and principles
An important set of transcription factors and coregulators that control erythropoiesis are described and emerging transcriptional mechanisms and principles are highlighted to underscore specific mechanisms which have potential to be broadly relevant to transcriptional control in diverse systems.
The murine placenta contains hematopoietic stem cells within the vascular labyrinth region.
It is demonstrated here that the placenta also harbors adult-repopulating HSCs, and placental cell expression of other HSC markers and transcription factors suggests that HSC emergence may occur in the Placenta, as has been proposed for other embryonic hematopoietic sites.
The placenta is a niche for hematopoietic stem cells.
It is shown that the mouse placenta functions as a hematopoietic organ that harbors a large pool of pluripotent HSCs during midgestation, and the expansion of the CD34(+)c-kit(+) HSC pool in the Placenta occurs prior to and during the initial expansion of HSCS in the fetal liver.
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage, which provides the first morphological description of embryonic H SCs and contribute new insight into their cellular origin.
Cbfa 2 is required for the formation of intraaortic hematopoietic clusters
  • Development
  • 1999
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.
It is shown that Cbfa2 is expressed in definitive hematopoietic progenitor cells, and in endothelial cells in sites from which these hematopolietic cells are thought to emerge.
A common precursor for hematopoietic and endothelial cells.
Findings provide strong evidence that the blast colony-forming cell represents the long-hypothesized hemangioblast, the common precursor of the hematopoietic and endothelial lineages.