SnapShot: Forkhead Transcription Factors II

  title={SnapShot: Forkhead Transcription Factors II},
  author={Geetu Tuteja and Klaus H. Kaestner},

The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

It is found that knockdown of SETDB1 impaired cell proliferation, led to an increase in reactive oxygen species (ROS) level through NADPH oxidase, and Setdb1 deficiency activated ROS downstream signaling pathways, including JNK and p38 MAPK, which possibly contributed to SSC apoptosis.

Cdc2: a monopotent or pluripotent CDK?

Interactions of cdc2 with pRb and with several important transcription factors may provide a clue to the pluripotent role of c dc2, and accumulation of evidence shows that cDC2 not only promotes G2‐M transition but is also capable of regulating G1 progress and G1‐S transition via association with multiple interphase cyclins.

Tumor suppressor maspin as a rheostat in HDAC regulation to achieve the fine-tuning of epithelial homeostasis.

The results are consistent with the hypothesis that maspin serves as an endogenous regulator of HDAC activity and suggest that the effect ofmaspin is primarily mediated by TGFβ, β-catenin/E-cadherin pathways, and network key nodes such as Abl kinase, p62, IL1, and caspases 6 and 8.

Identification of DNA-dependent Protein Kinase as a Cofactor for the Forkhead Transcription Factor FoxA2*

It is confirmed by chromatin immunoprecipitation that FoxA2 is one of the factors bound to the promoter-proximal enhancer of the gene encoding apolipoprotein AI and that it functions in synergy with the nuclear receptor hepatocyte nuclear factor-4α.

Akt, FoxO and regulation of apoptosis.

A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis

The role of FOXI3 in embryogenesis and bone development is summarized and its potential involvement in cancer progression is discussed with a focus on the bone metastasis.

Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes

Results indicate that Foxa1 plays a pro-APoptotic role by inhibiting the expression of anti-apoptotic gene bcl2 in A549 type II pneumocytes.



Forkhead transcription factors in immunology

The forkhead genes promise insight into the mechanisms of immunoregulation in several immune cell lineages, and their dysregulation likely contributes to the pathogenesis of several immunological disorders, suggesting that their study will lead to the development of novel therapeutic agents.

In control of biology: of mice, men and Foxes.

This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans.

Forkhead transcription factors: key players in development and metabolism.

Forkhead proteins are not among the largest transcription factor families, but display a remarkable functional diversity and are involved in a wide variety of biological processes.

The Jackson Laboratory

Mouse Genome Database (MGD), Mouse Genome Informatics Website, The Jackson Laboratory, Bar Harbor, Maine

  • Biochem. J. 397,
  • 2006

Ingenuity Pathways Analysis

  • Ingenuity Pathways Analysis
  • 2007

Human FOX gene family

  • Int. J. Oncol
  • 2004

Human FOX gene family

  • Int . J . Oncol .
  • 2004