The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase
- BiologyFrontiers in Genetics
It is found that knockdown of SETDB1 impaired cell proliferation, led to an increase in reactive oxygen species (ROS) level through NADPH oxidase, and Setdb1 deficiency activated ROS downstream signaling pathways, including JNK and p38 MAPK, which possibly contributed to SSC apoptosis.
Cdc2: a monopotent or pluripotent CDK?
- BiologyCell proliferation
Interactions of cdc2 with pRb and with several important transcription factors may provide a clue to the pluripotent role of c dc2, and accumulation of evidence shows that cDC2 not only promotes G2‐M transition but is also capable of regulating G1 progress and G1‐S transition via association with multiple interphase cyclins.
Tumor suppressor maspin as a rheostat in HDAC regulation to achieve the fine-tuning of epithelial homeostasis.
- BiologyCritical reviews in eukaryotic gene expression
The results are consistent with the hypothesis that maspin serves as an endogenous regulator of HDAC activity and suggest that the effect ofmaspin is primarily mediated by TGFβ, β-catenin/E-cadherin pathways, and network key nodes such as Abl kinase, p62, IL1, and caspases 6 and 8.
Forkhead Transcription Factors in Health and Disease.
- BiologyTrends in genetics : TIG
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
- BiologySeminars in cancer biology
Identification of DNA-dependent Protein Kinase as a Cofactor for the Forkhead Transcription Factor FoxA2*
- BiologyThe Journal of Biological Chemistry
It is confirmed by chromatin immunoprecipitation that FoxA2 is one of the factors bound to the promoter-proximal enhancer of the gene encoding apolipoprotein AI and that it functions in synergy with the nuclear receptor hepatocyte nuclear factor-4α.
A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis
- BiologyFront. Cell Dev. Biol.
The role of FOXI3 in embryogenesis and bone development is summarized and its potential involvement in cancer progression is discussed with a focus on the bone metastasis.
Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes
- BiologyCell Stress and Chaperones
Results indicate that Foxa1 plays a pro-APoptotic role by inhibiting the expression of anti-apoptotic gene bcl2 in A549 type II pneumocytes.
SHOWING 1-9 OF 9 REFERENCES
Forkhead transcription factors in immunology
- BiologyCellular and Molecular Life Sciences CMLS
The forkhead genes promise insight into the mechanisms of immunoregulation in several immune cell lineages, and their dysregulation likely contributes to the pathogenesis of several immunological disorders, suggesting that their study will lead to the development of novel therapeutic agents.
In control of biology: of mice, men and Foxes.
- BiologyThe Biochemical journal
This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans.
Forkhead transcription factors: key players in development and metabolism.
- BiologyDevelopmental biology
Forkhead proteins are not among the largest transcription factor families, but display a remarkable functional diversity and are involved in a wide variety of biological processes.
Mouse Genome Database (MGD), Mouse Genome Informatics Website, The Jackson Laboratory, Bar Harbor, Maine
- Biochem. J. 397,
Ingenuity Pathways Analysis
- Ingenuity Pathways Analysis
Human FOX gene family
- Int. J. Oncol
Human FOX gene family
- Int . J . Oncol .