SnapShot: B7/CD28 Costimulation

  title={SnapShot: B7/CD28 Costimulation},
  author={Alison M. Paterson and Vijay K. Vanguri and Arlene H Sharpe},
B7-1 (CD80) Inducible: APCs (slower kinetics than B7-2), T cells CD28 Constitutive: mouse (all T cells), human (95% of CD4+, 50% of CD8+ T cells), plasma cells, NK cells Stimulation of naive and previously activated T cells upon TCR ligation: ↑ proliferation (↓ p27Kip1, ↑ G1/S); ↑ cytokine production (↑ NFκB, ↑ IL2); ↑ survival (↑ Bcl-xL, ↑ survival of Tregs); ↑ glucose metabolism; provides T cell-dependent B cell help for class switching. Blockade of pathway to treat autoimmune infl ammatory… CONTINUE READING
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