SnapShot: B7/CD28 Costimulation

@article{Paterson2009SnapShotBC,
  title={SnapShot: B7/CD28 Costimulation},
  author={A. Paterson and V. Vanguri and A. Sharpe},
  journal={Cell},
  year={2009},
  volume={137},
  pages={974-974.e1}
}
  • A. Paterson, V. Vanguri, A. Sharpe
  • Published 2009
  • Medicine, Biology
  • Cell
  • B7-1 (CD80) Inducible: APCs (slower kinetics than B7-2), T cells CD28 Constitutive: mouse (all T cells), human (95% of CD4+, 50% of CD8+ T cells), plasma cells, NK cells Stimulation of naive and previously activated T cells upon TCR ligation: ↑ proliferation (↓ p27Kip1, ↑ G1/S); ↑ cytokine production (↑ NFκB, ↑ IL2); ↑ survival (↑ Bcl-xL, ↑ survival of Tregs); ↑ glucose metabolism; provides T cell-dependent B cell help for class switching. Blockade of pathway to treat autoimmune infl ammatory… CONTINUE READING

    Topics from this paper.

    An enigmatic tail of CD28 signaling.
    • 169
    • PDF
    A Proteomic View at T Cell Costimulation
    • 18
    The Role of Costimulatory Molecules in Directing the Functional Differentiation of Alloreactive T Helper Cells
    • 23
    • Highly Influenced
    Costimulatory pathways in transplantation
    • 73
    • Highly Influenced

    References

    Publications referenced by this paper.